Deprotection and Functionalization of Protective N‐Heterocycles Under Mild Conditions

A mild and versatile potassium trimethylsilanolate/butyronitrile (KOTMS/PrCN) reaction system for the deprotection and further functionalization of N‐heterocycles in a single step is developed. A range of N‐heterocycles, attached by various protecting groups, can be well transformed with good yields and functionality tolerance. The protocol features high efficiency, simple operation, and synthetic application.