WWOX attenuates the progression of gallbladder cancer by suppressing cellular glycolysis through the modulation of the P73/HIF-1α signaling pathway
WWOX interacts with the downstream protein p73, promoting the degradation of HIF-1α, which in turn reduces cellular glycolysis in a high-glucose environment and slows the progression of GBC.
Authors
- Bo Tang (ORCID: https://orcid.org/0000-0003-4734-1227)
- Qi-Cai Qu
- Kun Su
- Dongyun Cun
- Renchao Zou (ORCID: https://orcid.org/0000-0002-8598-5528)
- Xiaolong Yang (ORCID: https://orcid.org/0000-0002-8073-8675)
- Lianmin Wang
- Dongwei Ma (ORCID: https://orcid.org/0000-0002-6014-567X)
- Tao Wang (ORCID: https://orcid.org/0000-0001-7087-4596)
- Qiuhong Wang (ORCID: https://orcid.org/0000-0002-4852-8723)
- Tao Wu (ORCID: https://orcid.org/0000-0003-1071-8772)
Institutions
- Kunming Medical University (CN)
Publication Details
- Journal
- Tissue and Cell
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1016/j.tice.2025.102885
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00