Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury
σ-1R utilizes the AMPK/mTOR signaling pathway to enhance autophagy in sepsis-AKI, indicating that σ-1R may serve as a promising target for sepsis-AKI diagnosis and therapy.
Authors
- Jianfeng Zhang (ORCID: https://orcid.org/0000-0002-0851-9726)
- Yinan Zhang (ORCID: https://orcid.org/0000-0001-9934-4564)
- Zhongwei Huang (ORCID: https://orcid.org/0000-0001-7451-6497)
- Wei Jiang (ORCID: https://orcid.org/0009-0000-0922-2724)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- International Journal of General Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijgm.s506593
- Citations
- 3
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.42