Development of a novel single channel arteriole microphysiological system for characterizing leukocyte-endothelial interactions
In summary, our studies demonstrate the utility of the SCA model for studies of small vessel physiology under both normal and disrupted flow and to lay the groundwork for further development into a model for atherosclerosis. Additionally, our data emphasize the advantages of complex 3D assays over more traditional 2D cultures.
Authors
- Dan M. Cooper (ORCID: https://orcid.org/0000-0003-4022-0043)
- Shlomit Radom‐Aizik (ORCID: https://orcid.org/0009-0004-4023-7026)
- Christopher J. Hatch (ORCID: https://orcid.org/0000-0003-3996-7991)
- W. C. Hughes (ORCID: https://orcid.org/0000-0001-5419-4427)
- Sebastian Piombo
- C. Evangelista
Institutions
- University of California, Irvine (US)
- University of California System (US)
Publication Details
- Journal
- Journal of Clinical and Translational Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/cts.2025.49
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- University of California, Irvine
- National Center for Advancing Translational Sciences