Changes of Clinical Practice Patterns of Allergen Immunotherapy in Korea

This study aimed to identify recent changes of AIT treatment behaviors in real-world clinical practice using a questionnaire survey in Korea. The questionnaire on AIT prescriptions and practical experiences was distributed to all members of the Korean Academy of Asthma Allergy and Clinical Immunology in June 2022. The responses were analyzed and compared with the results from 2009 and 2017. In total, 115 responses (10.1%) were collected; 58 (50.4%) from internal medicine, 34 (29.6%) from pediatricians, and 21 (18.3%) from otolaryngologists. The prescription rate for subcutaneous immunotherapy (SCIT) was 53.8%, showing a decrease from those in 2009 and 2017; however, that for sublingual immunotherapy (SLIT) increased steadily, reaching 17.9% in 2009, 40.3% in 2017, and 46.2% in 2022. The prescription rates for asthma and atopic dermatitis increased by 4.6% and 7.9%, respectively. The most frequently prescribed allergens for SCIT in 2022 were house dust mites (32.9%), pollen (30.6%), and animal dander (28.2%), with the rate for animal dander showing a significant increase from 10.3% in 2009. Most physicians (93%) used mixed allergens for SCIT, with 42.8% using a combination of 5 or more allergens. Fifty-eight (67.4%) respondents reported cases of anaphylaxis during SCIT and 36.2% reported systemic adverse reactions during SLIT. In conclusion, SLIT prescriptions, AIT for asthma and atopic dermatitis, and AIT with animal dander increased significantly from 2009 to 2022. Serial surveys of AIT practices are helpful in identifying the changes of real-world clinical practice of AIT.

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Publication Details

Journal
Allergy Asthma and Immunology Research
Published
2025-01-01
DOI
https://doi.org/10.4168/aair.2025.17.2.271
Primary Topic
Allergic Rhinitis and Sensitization
Type
article
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article

Changes of Clinical Practice Patterns of Allergen Immunotherapy in Korea

Jin‐Young Min, Eun Kyo Ha, Jeong‐Hee Choi, Seon-Tae Kim et al.
1 links
Allergy Asthma and Immunology Research
Allergic Rhinitis and Sensitization
article

Changes of Clinical Practice Patterns of Allergen Immunotherapy in Korea

Jin‐Young Min, Eun Kyo Ha, Jeong‐Hee Choi, Seon-Tae Kim, Eun Hee Chung, Sun Hee Choi, Eun Ae Yang, Man Yong Han, Gwanghui Ryu, Yoo Seob Shin, Dong‐Ho Nahm, Hye Mi Jee, Jung Yeon Shim, Young‐Il Koh, Myong Soon Sung, Doo Hee Han, Yong Won Lee, Sung‐Yoon Kang, Sang Min Lee, So‐Young Park, Jung‐Won Park, Hwa Young Lee, Ju Hee Kim, Kyung Hee Park, Kyunghoon Kim, Young‐Soo Lee
article en

Abstract

This study aimed to identify recent changes of AIT treatment behaviors in real-world clinical practice using a questionnaire survey in Korea. The questionnaire on AIT prescriptions and practical experiences was distributed to all members of the Korean Academy of Asthma Allergy and Clinical Immunology in June 2022. The responses were analyzed and compared with the results from 2009 and 2017. In total, 115 responses (10.1%) were collected; 58 (50.4%) from internal medicine, 34 (29.6%) from pediatricians, and 21 (18.3%) from otolaryngologists. The prescription rate for subcutaneous immunotherapy (SCIT) was 53.8%, showing a decrease from those in 2009 and 2017; however, that for sublingual immunotherapy (SLIT) increased steadily, reaching 17.9% in 2009, 40.3% in 2017, and 46.2% in 2022. The prescription rates for asthma and atopic dermatitis increased by 4.6% and 7.9%, respectively. The most frequently prescribed allergens for SCIT in 2022 were house dust mites (32.9%), pollen (30.6%), and animal dander (28.2%), with the rate for animal dander showing a significant increase from 10.3% in 2009. Most physicians (93%) used mixed allergens for SCIT, with 42.8% using a combination of 5 or more allergens. Fifty-eight (67.4%) respondents reported cases of anaphylaxis during SCIT and 36.2% reported systemic adverse reactions during SLIT. In conclusion, SLIT prescriptions, AIT for asthma and atopic dermatitis, and AIT with animal dander increased significantly from 2009 to 2022. Serial surveys of AIT practices are helpful in identifying the changes of real-world clinical practice of AIT.

Allergy Asthma and Immunology ResearchVol. 17(2)
Gachon University (KR), Seoul National University (KR), Yonsei University (KR), Chungnam National University (KR), Samsung Medical Center (KR), Seoul National University Bundang Hospital (KR), Gumi University (KR), Kyung Hee University (KR), Gachon University Gil Medical Center (KR), Chonnam National University Hospital (KR), Hallym University Kangnam Sacred Heart Hospital (KR), Kangbuk Samsung Hospital (KR), The Catholic University of Korea Daejeon St. Mary's Hospital (KR), St. Mary's Hospital (US), CHA University Bundang Medical Center (KR), CHA University (KR), Catholic Kwandong University International St. Mary's Hospital (KR), Hallym University Dongtan Sacred Heart Hospital (KR), Kyung Hee University Hospital at Gangdong (KR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Ajou University (KR), Chung-Ang University (KR), Sungkyunkwan University (KR), Catholic University of Korea (KR), Dankook University (KR)
Openalex Percentile: Top 88%
Allergic Rhinitis and Sensitization
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