Simultaneous coherent–incoherent motion imaging in brain parenchyma
A phase-sensitive diffusion tensor magnetic resonance imaging (MRI) sequence is proposed with pulse timing optimization scheme to achieve velocity resolution of less than 20<i> </i>μm s<sup>-1</sup> and an integrated image reconstruction and velocity map generation pipeline. The application of ultra-slow flow relevant to neurofluids is enabled by the use of a recently developed, ultra-high-performance brain MRI gradient system. By simultaneously reconstructing magnitude and phase data, both metrics that characterize diffusive fluid motion and coherent velocity maps are calculated non-invasively in human subjects, time-resolved over the entire cardiac cycle. The resulting acquisition and reconstruction of velocity maps in brain parenchyma, enabled by high-performance brain imaging systems, promises to be an important approach to investigating ultra-slow neurofluid flow and glymphatic circulation.
Authors
- Chitresh Bhushan (ORCID: https://orcid.org/0000-0002-2935-2515)
- Maureen N. Hood (ORCID: https://orcid.org/0000-0002-6111-9262)
- H Douglas Morris (ORCID: https://orcid.org/0000-0002-7942-3748)
- Thomas Foo (ORCID: https://orcid.org/0000-0002-9016-1005)
- Angeliki Pollatou (ORCID: https://orcid.org/0000-0003-0379-4187)
- Vincent B. Ho (ORCID: https://orcid.org/0000-0001-6603-8384)
- Nastaren Abad (ORCID: https://orcid.org/0000-0002-7020-0492)
- Isabelle Heukensfeldt Jansen (ORCID: https://orcid.org/0009-0004-6490-4882)
- Elizabeth Metzger
- J. Kent Werner
- Afis Ajala (ORCID: https://orcid.org/0000-0002-1763-0274)
- Gail Kohls
- Sonja Skeete
- Luca Marinelli
- J. Kevin DeMarco
- Haymanot Yalewayker
- Samrawit Yalewayker
Institutions
- Uniformed Services University of the Health Sciences (US)
- Walter Reed National Military Medical Center (US)
Publication Details
- Journal
- Interface Focus
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1098/rsfs.2024.0041
- Citations
- 3
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- Congressionally Directed Medical Research Programs