Evaluation of Hepatoprotective Potential of Lamiaceae Family Plants in Rat Models of Alcohol, Paracetamol and Ranitidine-Induced Hepatotoxicity

The whole plant of Leucas zeylanica (Lamiaceae) was tested for hepatoprotection in Wistar rats after paracetamol (PCM), ethyl alcohol (ALC), and ranitidine (RTD) produced hepato the albino mouse acute toxicity maximum dosage was 2000 mg/kg. Six animal groups were utilized in all models. Modelling followed Silymarin. MELZWP contains saponins, carbohydrates, flavonoids, tannins, and phenolic from Leucas zeylanica whole plant. LD50 experiments showed these extracts did not kill or alter mice at 2000 mg/Kg body weight. Silymarin and MELZWP dosages increased thiopental sleeping time, wet liver weight, and volume than PCM, ALC, and RTD-induced hepatotoxic mice. Albumin (ALB) and protein (PRO) increased whereas ALT, ALP, AST, CHO, BILT, and TG dropped. Steatosis, necrosis, and other histological abnormalities were disallowed. Saponins and flavonoids protect the liver, study finds