Prediction of the Mechanism of Nephrolepis cordifolia (L) C. Presl against Disorders of Increased Blood Sugar and Lipid Levels using the Network Pharmacology Approach

Elevated blood sugar and lipid levels are a growing global health concern and N. Cordelia presents potential therapeutic benefits. Therefore, this study aimed to identify active compounds and mechanisms in N. cordifolia using a network pharmacology method. Active compounds were screened for target proteins associated with elevated blood sugar and lipids through PPI networks, enrichment analysis, docking, and MM/GB (PB) SA. The results showed 6 compounds from N. cordifolia, and 24 proteins were obtained using Cluster One analysis at the PPI network stage. An important mechanism, such as the PPAR signaling pathway was identified through enrichment. The proteins in this mechanism were FABP, PPARα, and PPARλ, obtained by docking and MMGB (PB) A. The key compounds were 9-Oxo-10 (E) and 12 (E)- octadecadienoic acid, suggesting the potential of N. cordifolia to overcome increased blood sugar and lipids.