Platelet-Activating Factor Disrupts the Nasal Epithelial Barrier Independently of the Platelet-Activating Factor Receptor Pathway
Our findings indicate that PAF has the potential to disrupt the nasal epithelial barrier in CRSwNP and may be linked to NLRP3 activation, while PAFR is not essential for this process. This discovery helps to explain why PAFR antagonists are ineffective in blocking PAF-mediated inflammation in clinical settings.
Authors
- Limin Zhao (ORCID: https://orcid.org/0000-0002-6144-6458)
- Luo Zhang (ORCID: https://orcid.org/0000-0002-0910-9884)
- Q. Z. Wang (ORCID: https://orcid.org/0000-0001-6616-7004)
- Ying Li (ORCID: https://orcid.org/0000-0002-3343-4492)
- Xinling Han (ORCID: https://orcid.org/0009-0003-0968-180X)
- Juan Tan (ORCID: https://orcid.org/0009-0002-1348-5222)
- Su Duan
- S.-D. Li
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Institute of Neurosurgery (CN)
Publication Details
- Journal
- Allergy Asthma and Immunology Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4168/aair.2025.17.2.212
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81