Clonidine Induced Acute Colonic Pseudo-obstruction: A Rare Adverse Effect

Objectives: Acute colonic pseudo-obstruction is a massive colonic dilation with signs and symptoms of colonic obstruction, but without a mechanical cause. Methodology: A 73-year-old hypertensive male on clonidine therapy developed spontaneous left basal ganglia haemorrhage with interventricular haemorrhage. While undergoing neurological treatment patient developed abdominal distension and constipation during hospital stay. All investigations done lead to the diagnosis of Acute colonic pseudo-obstruction (ACPO) (Ogilvie Syndrome). Results: Clonidine was suspected cause of Acute colonic pseudo-obstruction (ACPO). Hence clonidine was stopped and patient gradually improved.