Electrochemical Detection of Chloramphenicol with Different Modified Electrodes Based on the Metal-Cyclotriveratrylene Framework and Mesoporous Carbon

Design of high-performance electrochemical sensors for detection of antibiotics is greatly desirable for human health and ecological safety. Herein, a new metal-organic framework (MOF), namely, [Zn₂L(PDC)₂(H₂O)₂]·3H₂O (<b>1</b>), was synthesized with isophthalic acid (H₂PDC), Zn(II) cation, and cyclotriveratrylene-based ligand (L). By mechanical milling, <b>1</b> was incorporated with mesoporous carbon (MC) to produce <b>1</b>@MC. Subsequently, <b>1</b>@MC was decorated on different bare electrodes (glass carbon (GC), Au, Pt, or W electrode). The introduction of MC significantly improved the conductivity and the current response intensity for determination of chloramphenicol (CAP). Among these sensors, the current responses of CAP on <b>1</b>@MC(1:2)/GCE and <b>1</b>@MC(1:2)/Au were more intense. Markedly, they exhibited relatively wide linear ranges (0.5-400 μM on <b>1</b>@MC(1:2)/GCE and 1-400 μM on <b>1</b>@MC(1:2)/Au) and low limits of detection (0.15 μM on <b>1</b>@MC(1:2)/GCE and 0.48 μM on <b>1</b>@MC(1:2)/Au). Particularly, they can be used for the measurement of CAP in eye drop and milk sample with fine recoveries.