Effectiveness of BNT162b2 and Ad26.COV2.S vaccines against COVID-19-related hospitalisation amongst adult members of a private health insurance plan in South Africa during the Delta and Omicron periods: A test-negative case-control study
Vaccination offered significant protection against COVID-19-related hospitalisation in PLWH and the elderly, and is therefore an effective means of reducing severe outcomes in these high-risk populations in South Africa. VE against BA.4/5 waned with time since vaccination suggesting boosters may be necessary.
Authors
- Lundi Matoti
- Selaelo Mametja
- Siobhan Johnstone (ORCID: https://orcid.org/0000-0003-2033-270X)
- Michelle J. Groome (ORCID: https://orcid.org/0000-0001-5893-3725)
- Nicola Chiwandire (ORCID: https://orcid.org/0000-0002-4384-636X)
- Daniel B. Shapiro (ORCID: https://orcid.org/0000-0002-7719-9332)
- Mabatlo Semenya (ORCID: https://orcid.org/0000-0001-5678-1086)
- Cheryl Cohen (ORCID: https://orcid.org/0000-0003-0376-2302)
- Jolene Bultinck-Human
- Craig Getz
- Boldwin Moyo
- Carmen Whyte
Institutions
- National Health Laboratory Service (ZA)
- Midrand Graduate Institute (ZA)
- Government of South Africa (ZA)
Publication Details
- Journal
- Vaccine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.vaccine.2025.127068
- Primary Topic
- Vaccine Coverage and Hesitancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00