Piezo1 in PASMCs: Critical for Hypoxia-Induced Pulmonary Hypertension Development
This study provides evidence that Piezo1 expressed in PASMCs is critically involved in the pathogenesis of PH by controlling pulmonary vascular tone, arterial remodeling, and associated lung capillary rarefaction due to endothelial cell senescence.
Authors
- E. Born (ORCID: https://orcid.org/0000-0002-0557-3727)
- Serge Adnot (ORCID: https://orcid.org/0000-0001-5666-3063)
- Edyta Glogowska (ORCID: https://orcid.org/0000-0001-7989-9466)
- Mira Y. Gökyildirim (ORCID: https://orcid.org/0000-0001-9949-0609)
- Malika Arhatte
- Simone Kraut (ORCID: https://orcid.org/0000-0001-5856-8211)
- D. Fenner-Nau
- N. Vienney
- Norbert Weißmann (ORCID: https://orcid.org/0000-0003-2675-3871)
- Karin Quanz
- Fenja Knoepp (ORCID: https://orcid.org/0000-0003-4148-9415)
- Éric Honoré (ORCID: https://orcid.org/0000-0002-8007-0919)
- Larissa Lipskaia (ORCID: https://orcid.org/0000-0002-7998-8378)
- Geneviève Dérumeaux (ORCID: https://orcid.org/0000-0003-1471-1631)
- Andreas Güenther (ORCID: https://orcid.org/0000-0002-2187-0975)
- Shariq Abid
- Amal Houssaïni
- Élisabeth Marcos
- Ingrid Breitenborn-Mueller
Institutions
- Liaquat University of Medical & Health Sciences (PK)
- Justus-Liebig-Universität Gießen (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Cardio-Pulmonary Institute (DE)
- Institut de Pharmacologie Moléculaire et Cellulaire (FR)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1161/circresaha.124.325475
- Citations
- 18
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 20.96