Cytoplasmic Granulation of Human Oocytes at the Germinal Vesicle Stage as a Predictor of Their Ability to Spontaneous Maturation in Stimulated Cycles of In Vitro Fertilization

Objective: The purpose of this study was to analyze the patterns of cytoplasmic granulation of GV oocytes that differ in their ability to resume and complete meiotic maturation in vitro. Methods: Although in vitro fertilization (IVF) programs usually use mature (metaphase II, MII) oocytes, it is also possible to use diplotene oocytes at the germinal vesicle (GV) stage after their in vitro maturation (IVM). Results and Discussion: Morphological characteristics of native GV oocytes are promising predictors of their capacity for spontaneous maturation in stimulated cycles. Conclusions: It has been shown that the central granulation pattern negatively correlates with the ability of GV oocytes to spontaneously mature in vitro.