Phytochemistry and evaluation of the antimicrobial synergistic effects of the different organs of Magifera indica

In a context of limited resources and research into natural remedies, the different organs of Mangifera indica are among the natural substances used for the treatment of respiratory infections. In the literature, the antimicrobial activity of these organs has been described separately, but the synergistic effects between them remains unevaluated. This work aims to identify the possible synergistic effects that may exist between the leaves, steam barks and seeds of Mangifera indica. In this context, ethanolic extracts of different organs of Mangifera indica and their mixtures were carried out. Qualitative and quantitative phytochemical analyses and the antimicrobial activity on seven strains of microbes were determined. Among the different extracts, six strains (gram-positive and negative) of bacteria out of seven were sensitive to the extracts of the seeds and the mixture (seeds/steam barks) with inhibition diameters going up to 21.5 mm. Minimum inhibitory concentrations (MIC) between 5 and 20 mg/ml were noted. The lowest values are recorded at the level of seeds and the mixture (seeds/steam barks). The same fractions indicated the lowest minimum bactericidal concentration (MBC) (25 mg/ml). The phytochemical study of the most effective fractions indicated the common presence of families of compounds such as Reducing compound, Alkaloids, Flavonoids, Catechy tannins, Gallic tannins, Saponin, Terpenoids, Mucilages, O-heterosides. between all organs of the plant, seeds were more effective. A synergistic effect was observed by mixing seeds and steam barks. Mangifera indica seeds remain very promising substances in the search for new anti-infectious phyto-drugs.