Leucine Supplementation Counteracts the Atrophic Effects of HDAC4 in Rat Skeletal Muscle Submitted to Hindlimb Immobilization
Our results indicate that HDAC4 forced expression can alone induce skeletal muscle atrophy. In addition, our results indicate that leucine is dominant in blocking HDAC4 signaling and highlight the use of this amino acid as a therapeutic tool in conditions involving skeletal muscle atrophy.
Authors
- Paula Ketilly Nascimento Alves (ORCID: https://orcid.org/0000-0003-4550-6964)
- William J. Silva (ORCID: https://orcid.org/0000-0001-6969-3464)
- Volker Adams (ORCID: https://orcid.org/0000-0002-7955-7324)
- Siegfried Labeit (ORCID: https://orcid.org/0000-0002-9009-210X)
- André Freire Cruz (ORCID: https://orcid.org/0000-0001-9349-2742)
- Anselmo Sigari Moriscot (ORCID: https://orcid.org/0000-0003-3098-4613)
- Afonso M. Melazzo
Institutions
- Universidade de São Paulo (BR)
- Heidelberg University (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1002/mus.28411
- Citations
- 1
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico