Expression of miR-92a in Green Tea EGCG Preconditioned Adiposederived Stem Cells Ameliorates Inflammatory Response and Increases Cartilage Regeneration in RA Rats through KLF4/IL-17/MMP-2 Axis Modulation
The therapeutic effects of E-ADSCs and mic-ADSCs in RA were strongly associated with the modulation of the KLF4/IL-17/MMP-2 axis. These findings suggest that ADSCs preconditioned with EGCG and miR-92a hold considerable clinical promise for the treatment of RA.
Authors
- Tung‐Sheng Chen (ORCID: https://orcid.org/0000-0002-4400-3428)
- Wei-Wen Kuo (ORCID: https://orcid.org/0000-0003-3355-5566)
- Chih-Yang Huang
Institutions
- National Taiwan Normal University (TW)
- Asia University (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- Tzu Chi Foundation (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- Current Gene Therapy
- Published
- 2025-04-04
- DOI
- https://doi.org/10.2174/0115665232339721250313075146
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.25