Metformin Inhibits the Development of Lung Adenocarcinoma by Regulating the Expression of CCNA2 via E2F1
In conclusion, our findings revealed a novel mechanism for LUAD treatment in which MET can down-regulate CCNA2 expression via E2F1 and thus exert its anti-tumor effects.
Authors
- Chaoqun Lian (ORCID: https://orcid.org/0000-0003-4914-020X)
- Mei Tian (ORCID: https://orcid.org/0000-0002-1587-2114)
- Yinlong Huang
- Kai Zhang (ORCID: https://orcid.org/0000-0003-4242-0866)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-2488-5021)
- Luyao Wang (ORCID: https://orcid.org/0000-0003-1595-6593)
- Xiao‐Jing Wang (ORCID: https://orcid.org/0000-0001-8695-7361)
- Mengling Hu
Institutions
- Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-04-04
- DOI
- https://doi.org/10.2174/0113862073348968241101112455
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81