An In-silico Investigation of the Potential of Vitamin D as a 5-HT1A Receptor Agonist: A Molecular Modeling Approach for Evaluating its Pharmacological Prospects
Our study suggests that Vitamin D may function as an agonist for the 5-HT1A receptor, with ASP116 playing a critical role in binding. Yet, further <i>in vitro</i> and <i>in vivo</i> studies are necessary to validate these findings and explore the therapeutic potential of Vitamin D-derived compounds.
Authors
- Youness Kadil (ORCID: https://orcid.org/0000-0001-8011-5120)
- Mohamed Agoub (ORCID: https://orcid.org/0000-0002-3933-2868)
- Mohammed Mouhcine (ORCID: https://orcid.org/0000-0003-3982-5045)
- Houda Filali (ORCID: https://orcid.org/0000-0003-1563-2505)
- Imane Rahmoune (ORCID: https://orcid.org/0000-0002-1980-0214)
- Ibtihal Segmani (ORCID: https://orcid.org/0000-0001-7338-6942)
Institutions
- University of Hassan II Casablanca (MA)
Publication Details
- Journal
- Current Drug Discovery Technologies
- Published
- 2025-04-04
- DOI
- https://doi.org/10.2174/0115701638359333250314062331
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00