Growth differentiation factor 15: a valuable biomarker for the diagnosis and prognosis of late-onset form of multiple Acyl-CoA dehydrogenation deficiency
GDF15 levels were significantly elevated in symptomatic patients with late-onset MADD, likely due to mitochondrial dysfunction activating the ISR pathway. These findings suggest that GDF15 is a valuable biomarker for monitoring disease severity and symptomatology in patients with late-onset MADD.
Authors
- Chuanzhu Yan (ORCID: https://orcid.org/0000-0002-2191-5184)
- Bing Wen (ORCID: https://orcid.org/0000-0001-9601-2978)
- Yuan Sun (ORCID: https://orcid.org/0000-0002-5721-1402)
- Bing Zhao (ORCID: https://orcid.org/0000-0001-5720-4109)
- Jingwen Xu (ORCID: https://orcid.org/0000-0002-7026-9641)
- Tang Shuyao
- Lyu Jingwei
- Li Busu
- Ji Kunqian
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1186/s13023-025-03651-1
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China