Formulation and Characterizationof Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Resveratrol

Nanostructured lipid carriers based topical gel of Resveratrol was created with the aim of reducing inflammation. NLC is made up of propylene glycol as the co-surfactant, tween 20 as a surfactant, oleic acid as a liquid lipid, & stearic acid as a solid lipid. Particle size, SEM, DSC & FTIR were primarily utilised for analysing NLCs produced via solvent emulsification process. High entrapment efficiency, comprising 56.47% to 85.10%, has been demonstrated by the whole NLC. With 62.80nm of typical particle size & a 0.323 polydispersity index, which indicates uniformity in the distribution of particle sizes, formulation F1 was determined as the best formulation. Formulation F1's stability is shown by its larger zeta potential magnitude. The nanoparticulate dispersion was appropriately gelled & evaluated for in-vitro permeation study, homogeneity, spreadability, and physical appearance. The developed NLCs dispersion gel's in-vitro drug release pattern demonstrated both burst & prolong release. It was determined that resveratrol's created NLC gel shows promise for the drug's extended availability in skin tissues and may be applied to improve the treatment of inflammatory diseases.