Effect of Corn Silk on Olanzapine Induced Obesity in Rat

Background: Antipsychotics are recommended as the initial, treatment for schizophrenia and other psychotic disorders based on evidences. They are commonly prescribed for conditions like borderline personality disorder, obsessivecompulsive disorder, and forms of dementia including Alzheimer's disease. The effect of medications is limited due to side effects, those must be carefully balanced against their varying therapeutic benefits across these conditions. Objective: To study effect of corn silk extract in olanzapine induced obesity in rats. Methodology: Corn silk extract were made by reflux extraction method in which corn silk were collected at maturated stage, dried at room temperature and dry powder is refluxed in 70% ethanol, for 3 to 4 hour and after filtered and dry it. Six animals containing five groups were assigned. For 21 days dose (100, 200,400 mg/kg) were co-administered of CSE with olanzapine 2 mg/kg . Body weight, locomotor activity on day 1st and day 21st. On 21st day OGTT was conducted. Dissected organ weighed and collected visceral fat and estimation of lipid profile and calculate the oxidative stress of animals. Result: Corn silk extract ameliorates obesity in rats induced by olanzapine and hyperphagia by improved lipid metabolism.