Solubility Enhancement of Poorly Soluble Drug by Hot Melt Extrusion Technology

Improving solubility is a major hurdle for the pharmaceutical sector. Boosting solubility andd bioavailability of barely water-soluble medications is essential for efficient drug delivery. Solid dispersion, has gained popularity due to its capability of enhancing solubility and its adaptability in industrial processes. Other techniques like nanonization, micronization, complexation, lipid-based systems, and co-crystals also play vital roles in this area. Each method has its own advantages and constraints, and selection time and again relies on the particular characteristics of the medication and the intended result. It's captivating to observe how these advancements are influencing the future of pharmaceutical development. Its utilization is rising relative to traditional methods due to its process efficiency, solvent-free characteristics, and cost-effectiveness. The current study primarily addresses the process of categorization, preparation methods of solid dispersions, and their application to improve solubility of poorly soluble medications. Objective of current research work was to enhance solubility of weakly soluble medications employing hot melt extrusion technology (HME) and describes its utilization on solubility besides dissolution enhancement. By boosting solubility enhancement of weakly soluble medications, it leads to increase oral bioavailability and minimizing local as well as systemic side effects and it also increasing patient compliance. By using this technology prepared extrudes in optimized ratio of API: Polymer and compare solubility study of weakly soluble API against the extrudes prepared using solid solid dispersion technology.