Formulation and Development of Bilayer floating Tablet of Selective Drugs as GRDDS

The research work based on Bilayer floating tablet of selected drug as Sucralfate and Metoprolol succinate.. Sucralfate Immediate release layer containing Sucralfate 100 mg and total weight with excipients is 300 mg . Metoprolol succinate sustained layer containing Metoprolol succinate 50 mg and total weight with excipients is 200 mg is done. Metoprolol succinate layer (MSF10) the (DSFMS-500mg) produce Average Weight 501.7±0.26 (mg), Thickness 5.99±0.111 mm, Hardness 5.6±0.124KP, Friability 0.543%, FLT 22sec, TFT 18 hrs, Drug Content of Sucralfate 100.02%, Drug Content of Metoprolol Succinate is 99.98%. The TFT. is under acceptance criteria.(18-20hour). So the formulation is the best formulation as GRDDS.