Solubility Enhancement of Low Water Soluble Drug Using Granulating Agents

Class II drugs are characterized by their poor aqueous solubility and good permeability (As per BCS Classification). Therefore, formulating these types of drugs becomes very tricky and challenging. Incomplete and non-uniform release of these drugs causes less absorbance and poor bioavailability. Hence, there is huge requirement for build up a new strategy for this Class II category drugs for increasing their bioavailability and drug release. The low aqueous solubilization of API directly affects the drug release as well as its permeability through membrane or bioavailability. Therefore it is required to modify the solubility of these drugs by using suitable components which can enhance their solublization in the biological media. This study covered the solubility enhancing trials done with the active molecule Celecoxib. In this study multiple type of granulating agents were used for formulation of the tablet and their physicochemical characteristics were evaluated.