Formulation and Development of Sustained Release Tablets of Losartan Potassium using Chitosan as Rate Retarding Polymer

This study aims to develop and evaluate the SR tablets of Losartan Potassium (LP) using chitosan as rate retarding polymer. The tablets were developed by direct compression technique with varying concentration of chitosan at constat HPMC K100M concentration. The granules were characterised for various micromeritics characteristics followed by compression of tablets. The compressed tablets were characterised for physico chemical properties. The CI values for the lubricated blend ranged from 7.35% (F3) to 14.97% (F5). These values suggest that all formulations exhibit good to fair flow properties, with F3 showing the best flow characteristics (CI = 7.35%). The HR values of the lubricated blends varied between 1.079 (F3) and 1.176 (F5), indicating acceptable to good flowability across all formulations. All tablet batches showed acceptable physical properties. Content uniformity was well maintained across batches, with values ranging from 97.25% to 100.29%. The lowest friability was observed in F3 (0.35%), suggesting superior tablet robustness. The pure LP was found to be released 100% within 1 hour time period. F1 exhibited the highest dissolution, with 100% drug release at 24 hours, while F5 shows the slowest release, reaching only 52% at the same time point. The stability study of losartan potassium (LP) sustained-release (SR) tablets under accelerated conditions over six months indicates minimal variations in critical quality attributes, demonstrating good stability. This study underscores the potential of chitosan-based SR formulations for enhancing therapeutic efficacy in hypertension management.