Formulation and Development of Solid Oral Dosage Form of Millet and Evaluation of Antiulcer Activity using Ethanol Induced Ulcer in Rat

An unbalanced mix of harsh and defensive components, such as mucus from stomach, bicarbonate secretion, prostaglandins, and inherent resistance of the components of mucosal cells, leads to the stomach condition known as Peptic Ulcer Disease (PUD). PUD can be treated with a variety of medications, but their usage is restricted because of frequent side effects and low compliance. This led to a thorough search and ongoing investigation for alternatives to this treatment, which ultimately resulted in the discovery of a natural phytochemical, derived from plants that is thought to be an excellent conventional medication to treat PUD because it has less adverse effects and is more easily accessible and affordable. The objective of this in vivo antiulcer activity by using ethanol induced rat and to formulate and develop solid oral dosage form of millet. Millet formulation of tablets and capsules developed and physicochemical evaluation done. Five groups of albino wistar rats weighing 200–220g were created, with six individuals in each group. The ethanol induced ulcer procedure was used to induce ulcers.Animals were given Vehicle, Standard, and millet test orally. Observations for gastric content volume, pH, ulcer scoring, total acidity, pepsin activity and Histopathological studies were performed. The total acidity in the millet group at 300 mg and 600 mg was determined to be 93 and 68 mEq, respectively. Pepsin values for test 1 and test 2 were found to be 24.76 and 21.65 µg/ml. The millet treatment for the concentration of 300mg and 600mg treatment revealed a significant decline of gastric ulcer lesions. The millet with concentration of higher dose as 600mg shows the higher significant activity than the millet with concentration 300mg