Integrated multi-omics analysis reveals the functional and prognostic significance of lactylation-related gene PRDX1 in breast cancer
This study reveals the key role of PRDX1 in BRCA progression, mainly through the regulation of the tumor microenvironment and immune escape mechanisms. The survival prediction model based on PRDX1 shows robust prognostic potential, and future research should focus on integrating PRDX1 with other biomarkers to enhance the precision of personalised medicine.
Authors
- Yongdong Niu (ORCID: https://orcid.org/0000-0002-5392-3736)
- Yanping Yu (ORCID: https://orcid.org/0000-0002-3190-8519)
- Dongxu Ma
- Yiqin Xia (ORCID: https://orcid.org/0000-0002-2297-2471)
- Qinqing Wu
- J. Jin
- Heng Cao (ORCID: https://orcid.org/0000-0002-4385-7958)
- Xiang Wang (ORCID: https://orcid.org/0000-0001-5433-9905)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3389/fmolb.2025.1580622
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59