Combining network pharmacology and transcriptomics to validate and explore the efficacy and mechanism of Huayu Wan in treating non-small cell lung cancer
HYW effectively inhibits the malignant proliferation of NSCLC cells. The mechanism of its anti-cancer effects is likely mediated by the suppression of the PI3K/AKT/VEGFA signaling pathway. This finding provides new molecular insights into the potential therapeutic application of HYW in the treatment of lung cancer.
Authors
- Qian Yang (ORCID: https://orcid.org/0000-0001-5986-2682)
- Shaopu Hu
- Lei Gao
- Ruikang Zhong (ORCID: https://orcid.org/0000-0003-4914-6425)
- Min Jiang (ORCID: https://orcid.org/0000-0001-8835-891X)
- Guangyin Ou (ORCID: https://orcid.org/0000-0003-1054-0265)
- Tangke Gao (ORCID: https://orcid.org/0009-0000-0915-4127)
- Kaiwen Hu (ORCID: https://orcid.org/0000-0002-1258-9647)
- Jingyi Sun (ORCID: https://orcid.org/0009-0004-5000-1092)
Institutions
- Beijing University of Chinese Medicine (CN)
- Hebei University of Chinese Medicine (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1016/j.jep.2025.119724
- Citations
- 4
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.89