Clathrin is required for DNA damage repair
Genetic screening in Arabidopsis reveals that clathrin, a well-known regulator of endocytosis, is required for homologous recombination, a precise mechanism for repairing DNA double- strand breaks. Notably, CLATHRIN LIGHT CHAIN 2 localizes in the nucleus, suggesting that clathrin has non-canonical functions in the nucleus.
Authors
- Shunping Yan (ORCID: https://orcid.org/0000-0002-3665-1310)
- Xuerui Lu
- Tongbin Yang (ORCID: https://orcid.org/0009-0006-2341-7986)
- Lili Wang (ORCID: https://orcid.org/0000-0001-7457-6027)
- Leilei Duan
Institutions
- Huazhong Agricultural University (CN)
- Agricultural Genomics Institute at Shenzhen (CN)
- Key Laboratory of Guangdong Province (CN)
- Chinese Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Journal of Integrative Plant Biology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1111/jipb.13910
- Citations
- 4
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Huazhong Agricultural University