Identification of a novel cellobiose 2-epimerase from Acidobacteriota bacterium and its application for in-situ milk catalysis

To our knowledge, this is the first reported CE from the <i>Acidobacteriota</i> phylum, combining acidophilic activity with low-temperature adaptability. Acba-CE represents a breakthrough for <i>in situ</i> dairy modification, eliminating key bottlenecks in milk processing and enabling next-generation functional milk production.