<i>APOE</i> ε4 and Alzheimer's disease risk in Vietnamese populations
APOE ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), but this risk varies with ancestry. Little is known about the APOE ε4-AD risk in Vietnamese populations. We found two Vietnamese-language articles that included full APOE genotype data in Vietnamese AD dementia participants (N = 60) and controls (N = 30). APOE ε4/ε3 versus ε3/ε3 was associated with an odds ratio of 8.96 (95% confidence interval: 2.87–32.4) for AD dementia. Despite wide confidence intervals, the APOE ε4-AD odds ratio in Vietnamese populations appears similar to Korean and Japanese populations, who have the highest known APOE ε4-AD odds ratio.
Authors
- M. Matheson (ORCID: https://orcid.org/0009-0002-9095-5048)
- Hương Thanh Trần (ORCID: https://orcid.org/0000-0003-0722-0439)
- Trung-Anh Nguyen (ORCID: https://orcid.org/0009-0000-4132-9919)
- William G. Mantyh (ORCID: https://orcid.org/0000-0003-2096-2461)
- Adam Hansen (ORCID: https://orcid.org/0000-0002-4358-9842)
- Thang Pham (ORCID: https://orcid.org/0000-0002-2638-3260)
- Ashley Petersen (ORCID: https://orcid.org/0000-0001-7711-9657)
- Binh Thanh Nguyen (ORCID: https://orcid.org/0000-0002-5925-5273)
- Adam D. Block (ORCID: https://orcid.org/0009-0006-6447-4952)
- Thanh Binh Nguyen (ORCID: https://orcid.org/0000-0002-2260-8186)
- Huong Nguyen (ORCID: https://orcid.org/0009-0001-1010-7499)
- Ladson Hinton (ORCID: https://orcid.org/0000-0002-2285-6884)
- Viết Lực Trần
- Phuong Anh Thi Nguyen
Institutions
- University of Minnesota (US)
- Hanoi Medical University (VN)
- Vietnam National Children's Hospital (VN)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease Reports
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1177/25424823251334066
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 0.00