Profiling of omadacycline resistance in clinical MRSA: A nationwide genomic survey and in vitro evolutionary analysis
Susceptibility to omadacycline varied among different MRSA lineages, while some CC5 isolates exhibiting the resistance phenotype. The rpsJ gene serves as a general target for the evolution of omadacycline resistance and plays an important role in the refinement of future tetracycline derivatives.
Authors
- Xiaoming Wang (ORCID: https://orcid.org/0000-0003-1610-3840)
- Yunsong Yu (ORCID: https://orcid.org/0000-0003-2903-918X)
- Hemu Zhuang
- Yueqin Hong
- Feiteng Zhu
- Xin Cheng (ORCID: https://orcid.org/0000-0003-0032-0955)
- Shengnan Jiang (ORCID: https://orcid.org/0000-0002-8111-7571)
- Yiyi Chen (ORCID: https://orcid.org/0000-0003-0947-9102)
- Haiping Wang (ORCID: https://orcid.org/0000-0003-2055-8936)
- Zhengan Wang (ORCID: https://orcid.org/0000-0002-5579-6523)
- Lu Sun (ORCID: https://orcid.org/0000-0001-7041-1137)
- Mengzhen Chen (ORCID: https://orcid.org/0009-0004-2024-830X)
- Yeqiong Liu
Institutions
- Hangzhou Normal University (CN)
- Sir Run Run Shaw Hospital (CN)
- Hangzhou Center for Disease Control and Prevention (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107499
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18