GSDME knockout alleviates hematopoietic stem cell irradiation injury and aggravates myeloid-biased differentiation
GSDME is vital for the survival and differentiation of HSCs, and its absence promotes myeloid-biased differentiation postirradiation. These findings highlight the critical role of GSDME in radiation-induced hematopoietic injury, particularly in the myeloid differentiation of HSCs.
Authors
- Lulu Su (ORCID: https://orcid.org/0000-0002-2244-6674)
- Bowen Guan (ORCID: https://orcid.org/0000-0003-2553-1716)
- Yinping Dong (ORCID: https://orcid.org/0000-0003-4186-6786)
- Wenxuan Li (ORCID: https://orcid.org/0000-0003-2893-9899)
- Aimin Meng (ORCID: https://orcid.org/0000-0002-0781-1346)
- Qidong Huo
- Deguan Li (ORCID: https://orcid.org/0000-0003-3194-9334)
- Xinyue Wang (ORCID: https://orcid.org/0000-0002-8634-9590)
- Yuquan Wang (ORCID: https://orcid.org/0000-0003-2379-7924)
- Yanhua Lu (ORCID: https://orcid.org/0000-0002-1367-6080)
Institutions
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3389/fcell.2025.1544320
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00