Evaluating the safety, pharmacokinetics and efficacy of phage therapy in treating fracture-related infections with multidrug-resistant Staphylococcus aureus: intravenous versus local application in sheep
PT is a safe adjunct to antibiotic treatment for FRI, however, phage neutralization developed rapidly and was accelerated in infected hosts. Further research is required to optimize phage selection, dosing, and delivery methods to enhance its therapeutic potential as an adjunct to conventional antibiotic therapy, particularly in the face of challenges such as rapid clearance and phage neutralization.
Authors
- Daniel Arens (ORCID: https://orcid.org/0000-0002-2705-0812)
- T. Fintan Moriarty (ORCID: https://orcid.org/0000-0003-2307-0397)
- M.H.J. Verhofstad (ORCID: https://orcid.org/0000-0001-8448-5903)
- Charalampos G. Zalavras (ORCID: https://orcid.org/0000-0002-7576-3374)
- Jolien Onsea (ORCID: https://orcid.org/0000-0002-5096-5789)
- Michael J. Raschke (ORCID: https://orcid.org/0000-0002-0265-8098)
- Marco Chittò (ORCID: https://orcid.org/0000-0002-9813-9515)
- Christian Peez (ORCID: https://orcid.org/0000-0001-8055-289X)
- Caroline Constant (ORCID: https://orcid.org/0000-0002-7846-5612)
- William Todd Obremskey (ORCID: https://orcid.org/0000-0002-8942-1842)
- Leopold Henssler (ORCID: https://orcid.org/0009-0006-3644-5863)
- Andrej Trampuž (ORCID: https://orcid.org/0000-0002-5219-2521)
- Stephan Zeiter (ORCID: https://orcid.org/0000-0002-8155-4202)
- Willem‐Jan Metsemakers (ORCID: https://orcid.org/0000-0002-4114-9093)
- Baixing Chen (ORCID: https://orcid.org/0000-0002-4158-6816)
Institutions
- University of Southern California (US)
- Queensland University of Technology (AU)
- AO Foundation (CH)
- Erasmus MC (NL)
- University Hospital Regensburg (DE)
- Los Angeles Medical Center (US)
- University Hospital Münster (DE)
- Vanderbilt University Medical Center (US)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3389/fcimb.2025.1547250
- Citations
- 8
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 13.73