Assessment of ventilation heterogeneity and particle deposition in asthmatics using combined SPECT/CT imaging and computational modeling approaches
Our cluster-informed CFPD-based approach enhances the understanding of ventilation heterogeneity in asthma and holds potential for refining strategies for inhalational therapies.
Authors
- Andrew Babiskin
- Nizar N. Jarjour (ORCID: https://orcid.org/0000-0003-0170-8927)
- Mario Castro (ORCID: https://orcid.org/0000-0002-5174-2405)
- Eric A. Hoffman (ORCID: https://orcid.org/0000-0001-8456-9437)
- David W. Kaczka (ORCID: https://orcid.org/0000-0003-4378-5242)
- Sean B. Fain (ORCID: https://orcid.org/0000-0001-5461-0646)
- John V. Fahy (ORCID: https://orcid.org/0000-0001-5427-9308)
- Jiwoong Choi (ORCID: https://orcid.org/0000-0002-7427-2979)
- Mark L. Schiebler (ORCID: https://orcid.org/0000-0002-9120-5428)
- SERPIL CEM ERZURUM (ORCID: https://orcid.org/0000-0001-5202-9065)
- Minori Kinjo
- Frank Li (ORCID: https://orcid.org/0000-0002-8205-3397)
- Benjamin M. Smith (ORCID: https://orcid.org/0000-0002-0619-5799)
- Bruce David Levy (ORCID: https://orcid.org/0000-0001-9515-5731)
- Sally E. Wenzel (ORCID: https://orcid.org/0000-0002-4242-0164)
- Ross Walenga (ORCID: https://orcid.org/0000-0003-3261-4245)
- Alejandro P. Comellas (ORCID: https://orcid.org/0000-0003-1521-7520)
- Sanghun Choi (ORCID: https://orcid.org/0000-0001-5030-0296)
- Prathish K. Rajaraman (ORCID: https://orcid.org/0000-0002-9796-8653)
- Ching-Long Lin
- Elliot Israel
- Xuan Zhang (ORCID: https://orcid.org/0000-0003-3845-3374)
Institutions
- University of Iowa (US)
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- United States Food and Drug Administration (US)
- Center for Drug Evaluation and Research (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Kansas (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- McGill University Health Centre (CA)
- Kyungpook National University (KR)
- Columbia University (US)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1016/j.ejps.2025.107093
- Citations
- 3
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 4.56