Prospective Study of ADAMTS13 and von Willebrand Factor’s Role in the Prediction of Outcomes in Acute Ischemic Stroke

<b>Background:</b> In this prospective study, the prognostic role of ADAMTS13 activity and von Willebrand (VWF) antigen (VWF: Ag) levels in ischemic stroke outcomes was investigated. <b>Methods:</b> Patients diagnosed with acute ischemic stroke were prospectively enrolled in this study, while samples for ADAMTS13 activity and VWF: Ag level measurements were collected upon their admission to our unit. The National Institutes of Health Stroke Scale (NIHSS) score was estimated upon admission and at discharge. The modified Rankin scale for neurologic disability (Rankin) score was estimated based on the patient's history before the stroke onset, during admission (RankinAdm), and at discharge (RankinDis). <b>Results:</b> In the study, 29 patients with a median age of 82.5 (51, 92) were included. In univariate analysis, ADAMTS13 activity during admission was associated with platelet values at the same time point (r = 0.12, <i>p</i> = 0.01) and VWF: Ag levels were associated with age (r = 0.439, <i>p</i> = 0.04), previous ischemic stroke (r = 0.9176, <i>p</i> = 0.031), and glucose levels (r = 0.64, <i>p</i> = 0.049). Associations between ADAMTS13/VWF: Ag Ratio with RankinDis (r = 0.3253, <i>p</i> = 0.03), and the change between RankinDis and RankinAdm (r = 0.1589, <i>p</i> = 0.014) were identified. Additionally, VWF: Ag levels during admission were correlated with RankinDis (r = 0.0072, <i>p</i> = 0.049). <b>Conclusions:</b> These markers might be useful as biomarkers for the prediction of poor outcomes after stroke.