Estimation of the specific absorption rate in magnetic hyperthermia studies via the modified Box-Lucas and extended-CSM methods

This paper reports on the synthesis and characterization of magnetite nanoparticles and a methodology for estimating their specific absorption rate when subjected to an oscillatory magnetic field. Nanoparticles of 15 and 31 nm in size were analyzed. The methodology uses the modified Box-Lucas function and the extended-corrected slope method, from which eddy current heating and temperature variations due to thermalizing processes are removed from these nanoparticles in colloidal form, either from thermalized or nonthermalized samples. In particular, large errors appeared with concentrations lower than 4 mg/ml, and f = 235.6 kHz and B = 11.63 mT. Whereas the modified Box-Lucas functions removed the extra heating and/or nonmagnetic heating of the colloidal samples from the numerical fitting analysis, the extended-corrected slope method removed them by subtracting the slopes.