Frog Skin Peptides Hylin-a1, AR-23, and RV-23: Promising Tools Against Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae Infections
Our study identifies Hylin-a1, AR-23, and RV-23 as promising candidates against Gram-negative bacterial infections with a favorable therapeutic profile. This effect could be related to their great flexibility, as evidenced by circular dichroism data, confirming that the peptides could assume an α-helical conformation interacting with bacterial membranes.
Authors
- Annalisa Chianese (ORCID: https://orcid.org/0000-0002-1648-4519)
- Anna De Filippis (ORCID: https://orcid.org/0000-0002-0395-7962)
- Francesca Palma (ORCID: https://orcid.org/0009-0004-8957-0719)
- Nunzianna Doti (ORCID: https://orcid.org/0000-0003-2952-6658)
- Massimiliano Galdiero (ORCID: https://orcid.org/0000-0002-1576-6290)
- Alessandra Monti (ORCID: https://orcid.org/0000-0002-6789-7057)
- Annalisa Ambrosino (ORCID: https://orcid.org/0009-0004-8381-0400)
- Rosa Giugliano (ORCID: https://orcid.org/0000-0001-9923-3194)
- Carla Zannella (ORCID: https://orcid.org/0000-0001-7991-8700)
- Marina Acunzo (ORCID: https://orcid.org/0009-0007-1483-7054)
- Preetu Parimal
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Institute of Biostructure and Bioimaging (IT)
- National Research Council (IT)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3390/antibiotics14040374
- Citations
- 3
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 3.55