Computational Construction of Sequential Efficient Designs for the Second-Order Model

Sequential experimental designs enhance data collection efficiency by reducing resource usage and accelerating experimental objectives. This paper presents a model-driven approach to sequential Latin hypercube designs (SLHDs) tailored for second-order models. Unlike traditional model-free SLHDs, our method optimizes a conditional A-criterion to improve efficiency, particularly in higher dimensions. By relaxing the restriction of non-replicated points within equally spaced intervals, our approach maintains space-filling properties while allowing greater flexibility for model-specific optimization. Using Sobol sequences, the algorithm iteratively selects good points, enhancing conditional A-efficiency compared to distance minimization methods. Additional criteria, such as D-efficiency, further validate the generated design matrices, ensuring robust performance. The proposed approach demonstrates superior results, with detailed tables and graphs illustrating its advantages across applications in engineering, pharmacology, and manufacturing.