Early changes in inflammation-related proteins in the cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage
This study demonstrates the feasibility of measuring a large number of inflammatory proteins in CSF and plasma from aSAH patients soon after injury. Despite the small sample size and limitations of the control group, we identified several previously reported "hits" that may offer prognostic utility and/or therapeutic potential for aSAH patients: CXCL12, IL-15, and SAA1.
Authors
- Justin F. Fraser (ORCID: https://orcid.org/0000-0002-5980-3989)
- Linda J. Van Eldik (ORCID: https://orcid.org/0000-0002-8139-6400)
- Caleb S. Bailey (ORCID: https://orcid.org/0000-0001-8913-079X)
- Ishara S. Ariyapala (ORCID: https://orcid.org/0000-0003-4979-4094)
- Hunter Moseley (ORCID: https://orcid.org/0000-0003-3995-5368)
- Robert M Flight (ORCID: https://orcid.org/0000-0001-8141-7788)
- Josh M. Morganti (ORCID: https://orcid.org/0000-0002-4183-0049)
- Bingqing Zhang (ORCID: https://orcid.org/0000-0003-0739-0956)
- Kevin W. Hatton (ORCID: https://orcid.org/0000-0002-9388-0232)
- David J. Braun (ORCID: https://orcid.org/0000-0002-6967-0489)
- Tae Kyoung Kim (ORCID: https://orcid.org/0000-0001-5193-1428)
Institutions
- University of Kentucky (US)
- Alamance Community College (US)
- Markey Cancer Center (US)
- Institut Agama Islam Negeri Bengkulu (ID)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108304
- Citations
- 1
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 1.39