5-Hydroxytryptamine receptors in GtoPdb v.2025.1
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [200] and subsequently revised [182]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 499]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [478, 394]).
Authors
- Michael R. Hamblin (ORCID: https://orcid.org/0000-0001-6431-4605)
- Rebecca Hills (ORCID: https://orcid.org/0000-0002-4305-5373)
- Katharine Herrick‐Davis
- Bryan L. Roth (ORCID: https://orcid.org/0000-0002-0561-6520)
- Aline Dumuis
- Klaus Peter Latté (ORCID: https://orcid.org/0000-0002-0553-9078)
- Trevor Sharp (ORCID: https://orcid.org/0000-0001-7434-9713)
- Derek N. Middlemiss
- Frank D. Yocca
- Ewan J. Mylecharane
- Carlos M. Villalón (ORCID: https://orcid.org/0000-0003-4117-1343)
- Julie G. Hensler
- Ricardo Andrade (ORCID: https://orcid.org/0000-0002-3969-7840)
- M. Hamon (ORCID: https://orcid.org/0000-0002-6579-1849)
- Andrew J. Sleight
- Luc Maroteaux (ORCID: https://orcid.org/0000-0002-9499-8603)
- Joël Bockaert
- Amy Butler
- René Hen
- John A. Peters (ORCID: https://orcid.org/0000-0002-4277-4245)
- Stephen J. Peroutka
- Paul Hartig
- Gordon S. Baxter
- John F. Neumaier (ORCID: https://orcid.org/0000-0002-1763-7118)
- Daniël Hoyer (ORCID: https://orcid.org/0000-0002-1405-7089)
- Nicholas M. Barnes (ORCID: https://orcid.org/0000-0003-4624-9672)
- Graeme R. Martin
- Marlene L. Cohen
- Manfred Göthert
- Theresa A. Branchek
- P.P.A. Humphrey
- Richard M. Eglen
- Pramod R. Saxena
Publication Details
- Journal
- IUPHAR/BPS Guide to Pharmacology CITE
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2218/gtopdb/f1/2025.1
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00