Alpha-estradiol and (R)-(−)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex
Targeting GLI1 G4 structures with alpha-estradiol and (R)-(-)-ibuprofen effectively inhibits gastric cancer progression by blocking GLI1/PRKACB signaling. This study highlights G4-targeted therapy as a novel and clinically translatable strategy for gastric cancer treatment.
Authors
- Jingtan Li
- Jiaying Cai
- Yanfei Jia (ORCID: https://orcid.org/0000-0002-0670-1604)
- Lulu Zhang (ORCID: https://orcid.org/0000-0003-1865-5024)
- Xiaoli Ma (ORCID: https://orcid.org/0000-0003-0279-8354)
- Jing Wang (ORCID: https://orcid.org/0000-0002-9538-8452)
- Pan Pan (ORCID: https://orcid.org/0000-0002-9573-9443)
- Qiang Li (ORCID: https://orcid.org/0000-0002-2354-177X)
- Qingqing Xian
- Haiji Sun
- Jingting Wang
Institutions
- Shandong Normal University (CN)
- Jinan Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3389/fphar.2025.1492694
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province