Are Polymorphisms Within the Fructosamine-3-Kinase Gene Associated With the Discordance Between HbA1c and Other Measures of Glycemia?
Discrepancies between glycated hemoglobin (HbA1c) and other measures of glycemia have been reported, and these may be due to nonglycemic factors. We assessed the association between FN3K gene variants and the discrepancy between HbA1c and fructosamines as indicated by the glycation gap. Our results showed significant associations between the FN3K SNP genotypes and the glycation gap in individuals with diabetes mellitus. Polymorphisms in the FN3K gene are associated with the glycation gap, suggesting a potential genetic contribution to the discrepancy in glycemic control measures.
Authors
- Tandi E. Matsha (ORCID: https://orcid.org/0000-0001-5251-030X)
- Elvis N. Ngwa
- Annalise E. Zemlin (ORCID: https://orcid.org/0000-0001-7621-4679)
- André Pascal Kengne (ORCID: https://orcid.org/0000-0002-5183-131X)
- Glenda M. Davison (ORCID: https://orcid.org/0000-0003-2726-8114)
- Cindy George (ORCID: https://orcid.org/0000-0002-4561-0529)
- Rajiv T. Erasmus (ORCID: https://orcid.org/0000-0001-6831-4215)
- Dipuo D. Motshwari (ORCID: https://orcid.org/0000-0003-0740-1440)
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- University of Cape Town (ZA)
- Cape Peninsula University of Technology (ZA)
- Stellenbosch University (ZA)
- Sefako Makgatho Health Sciences University (ZA)
- African Population and Health Research Center (KE)
Publication Details
- Journal
- Diabetes
- Published
- 2025-04-04
- DOI
- https://doi.org/10.2337/db24-0606
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00