Upregulation of SSTR2 Expression and Radioligand Binding of [<sup>18</sup>F]SiTATE in Neuroendocrine Tumour Cells with Combined Inhibition of Class I HDACs and LSD1
Combined inhibition of class I HDACs and LSD1 potently increases SSTR2 expression and consequently radioligand binding and might thus be a putative strategy to improve the outcome of PRRT therapy in patients with NETs.
Authors
- Harun Ilhan (ORCID: https://orcid.org/0000-0003-0409-1942)
- Umberto Macciò (ORCID: https://orcid.org/0000-0003-3253-3787)
- Gerald Spoettl
- Felix Beuschlein (ORCID: https://orcid.org/0000-0001-7826-3984)
- Christoph Josef Auernhammer (ORCID: https://orcid.org/0000-0001-8087-3722)
- Alessa Fischer (ORCID: https://orcid.org/0000-0003-4555-8334)
- Peter Bartenstein (ORCID: https://orcid.org/0009-0005-0734-4994)
- Michael Orth (ORCID: https://orcid.org/0000-0002-4608-7151)
- Ashley Barry Grossman (ORCID: https://orcid.org/0000-0003-1176-6186)
- Constanze Hantel (ORCID: https://orcid.org/0009-0000-8906-2563)
- Katharina Wang (ORCID: https://orcid.org/0000-0002-7795-1395)
- Karel Pacák (ORCID: https://orcid.org/0000-0002-3541-3767)
- Christine Spitzweg (ORCID: https://orcid.org/0000-0002-0413-9697)
- Svenja Nölting (ORCID: https://orcid.org/0000-0002-7064-590X)
- Lea Peischer
- Simon Lindner (ORCID: https://orcid.org/0009-0007-4379-4436)
- Kathrin Zitzmann (ORCID: https://orcid.org/0009-0001-2341-3161)
- Julian Maurer
Institutions
- National Institutes of Health (US)
- The Royal Free Hospital (GB)
- LMU Klinikum (DE)
- University of Oxford (GB)
- Ihre-Radiologen (DE)
- University Children's Hospital Tübingen (DE)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Neuroendocrinology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1159/000545073
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Deutsche Forschungsgemeinschaft
- Universität Zürich