Integrated Metabolomics and Spatial Transcriptomics of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism as a Biomarker of Progression
Cystic fluid polyamines offer utility for determining risk of malignancy of IPMNs that is complementary to CA19-9 and that has potential to aid in clinical management of patients with IPMNs.
Authors
- Ranran Wu (ORCID: https://orcid.org/0000-0002-6276-1425)
- Yaxi Li (ORCID: https://orcid.org/0000-0002-9258-0705)
- Yihui Chen (ORCID: https://orcid.org/0000-0002-3528-6104)
- Ehsan Irajizad (ORCID: https://orcid.org/0000-0001-7510-4849)
- C. Max Schmidt (ORCID: https://orcid.org/0000-0003-2447-2128)
- Ricardo A. León-Letelier (ORCID: https://orcid.org/0000-0001-7575-0453)
- Mark W. Hurd (ORCID: https://orcid.org/0000-0002-6102-4925)
- Rongzhang Dou (ORCID: https://orcid.org/0000-0002-2566-7843)
- Hamid Khoshfekr Rudsari (ORCID: https://orcid.org/0000-0002-7856-0038)
- Samir Hanash (ORCID: https://orcid.org/0000-0002-4210-1593)
- Jody V. Vykoukal (ORCID: https://orcid.org/0000-0001-7797-627X)
- Anirban Maitra (ORCID: https://orcid.org/0000-0001-7923-9978)
- Kim‐Anh Do (ORCID: https://orcid.org/0000-0001-8710-7131)
- Michele Yip-Schneider
- Johannes Francois Fahrmann (ORCID: https://orcid.org/0000-0001-5088-0198)
- Jianjun Zhang (ORCID: https://orcid.org/0000-0003-2179-2388)
- Jennifer B. Dennison (ORCID: https://orcid.org/0000-0003-3067-0972)
- Rachelle Spencer
- Riccardo Ballarò (ORCID: https://orcid.org/0000-0001-5505-9024)
- Rahmah Ejaz
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Wuhan University (CN)
- Indiana University Bloomington (US)
- Zhongnan Hospital of Wuhan University (CN)
- Richard M. Fairbanks Foundation (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2931
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- University of Texas MD Anderson Cancer Center
- National Cancer Institute