Formylpeptide receptors in GtoPdb v.2025.1
The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [150]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLF) and endogenous ligands such as lipoxin A4 (LXA4), 15-epi-lipoxin A4, annexin I , cathepsin G, amyloid β42, serum amyloid A and spinorphin, derived from β-haemoglobin. FPR1 also serves as a plague receptor for selective destruction of human immune cells by Y. pestis [135]. The FPR1/2 agonists 'compound 17b' and 'compound 43' have shown cardiac protective functions [149, 64].
Authors
- Jeffrey M. Drazen (ORCID: https://orcid.org/0000-0003-2715-9890)
- Sven‐Erik Dahlén (ORCID: https://orcid.org/0000-0002-4993-4002)
- Charles N. Serhan (ORCID: https://orcid.org/0000-0003-4627-8545)
- Cláes Dahlgren (ORCID: https://orcid.org/0000-0002-8946-5714)
- Jilly F. Evans
- G. Enrico Rovati (ORCID: https://orcid.org/0000-0002-8788-9783)
- Magnus Bäck (ORCID: https://orcid.org/0000-0003-0853-5141)
- Richard D. Ye (ORCID: https://orcid.org/0000-0002-2164-5620)
- Philip M. Murphy (ORCID: https://orcid.org/0000-0002-1080-8201)
- Nan Chiang (ORCID: https://orcid.org/0000-0003-1963-1585)
- Takehiko Yokomizo (ORCID: https://orcid.org/0000-0002-5219-1553)
- Mark T. Quinn (ORCID: https://orcid.org/0000-0001-8114-5073)
- Marc Parmentier (ORCID: https://orcid.org/0000-0001-8081-4685)
- Takao Shimizu (ORCID: https://orcid.org/0000-0002-9079-1357)
- Ji Ming Wang (ORCID: https://orcid.org/0000-0002-7381-5695)
- François Boulay
- Craig Gérard
Publication Details
- Journal
- IUPHAR/BPS Guide to Pharmacology CITE
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2218/gtopdb/f23/2025.1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00