Targeting Hsp70 Immunosuppressive Signaling Axis with Lipid Nanovesicles: A Novel Approach to Treat Pancreatic Cancer
These preclinical results reveal a novel immunotherapeutic approach to potentially improve the outcome of PDAC treatment in humans.
Authors
- Wen-Hai Shao (ORCID: https://orcid.org/0000-0002-4397-0539)
- Subrahmanya Vallabhapurapu
- Bořivoj Vojtěšek (ORCID: https://orcid.org/0000-0001-6194-3705)
- Xiaoyang Qi (ORCID: https://orcid.org/0000-0001-5363-1760)
- Petr Müller (ORCID: https://orcid.org/0000-0002-8404-4494)
- Ahmet Kaynak (ORCID: https://orcid.org/0000-0001-6551-1125)
- Vladimir Y. Bogdanov (ORCID: https://orcid.org/0000-0003-4968-1129)
- Clayton S. Lewis (ORCID: https://orcid.org/0000-0002-4694-9970)
- Eric P. Smith (ORCID: https://orcid.org/0000-0002-9606-0109)
- Joseph Ahn (ORCID: https://orcid.org/0000-0001-8528-4919)
- Robert S. Franco (ORCID: https://orcid.org/0009-0005-4996-3603)
- Keith Stringer
- Harold W. Davis
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- National Institutes of Health (US)
- Center for Scientific Review (US)
- Masaryk Memorial Cancer Institute (CZ)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3390/cancers17071224
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Pancreatic Cancer Action Network
- University of Cincinnati
- Hope Foundation
- Grantová Agentura České Republiky
- National Institutes of Health