Surface Modification of Islets With L-DOPA–KF7 Enhances Islet Survival by Inhibiting IBMIR in Intrahepatic Islet Transplantation
KEATSTF-fragment (KF7), an inhibitor of 14-3-3ζ-c-Src-integrin-β3 complex, effectively suppresses the instant blood-mediated inflammatory response by reducing thrombosis without increasing the risk of bleeding. The dopamine precursor 3,4-dihydroxy-l-phenylalanine (L-DOPA) can simply bind to the surface of islets without affecting cell viability or functionality, thus providing potential opportunities for clinical applications. A composite L-DOPA-KF7 coating effectively inhibited infiltration of platelets and CD11+ cells, thereby enhancing the efficacy of islet transplantation.
Authors
- Jinliang Duan
- Bowen Zhuang (ORCID: https://orcid.org/0000-0002-8225-5714)
- Fang Bai (ORCID: https://orcid.org/0000-0003-0639-8104)
- Daopeng Yang (ORCID: https://orcid.org/0000-0002-5617-9308)
- Yibo Hou (ORCID: https://orcid.org/0000-0001-5582-5243)
- Zepeng Lin
- Bin Qiao
- Xue Ma (ORCID: https://orcid.org/0009-0008-2012-2140)
- Xiaoyan Xie (ORCID: https://orcid.org/0000-0002-9761-9525)
- Xiaoshun He (ORCID: https://orcid.org/0000-0001-5317-9612)
- Anbin Hu (ORCID: https://orcid.org/0000-0003-0806-4968)
- Xiaofeng Zhu
- Haibin Ji
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Diabetes
- Published
- 2025-04-04
- DOI
- https://doi.org/10.2337/db24-1033
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01