Inhibition of Interleukin-8/C-X-C Chemokine Receptor 2 Signaling Axis Prevents Tumor Growth and Metastasis in Triple-Negative Breast Cancer Cells
Our results underscore the significant role of the IL-8/CXCR2 signaling axis in the metastasis of TNBC and suggest that CXCR2 inhibitors such as SB225002 may be promising therapeutic agents for TNBC patients.
Authors
- Seok Jin Nam (ORCID: https://orcid.org/0000-0003-1072-8954)
- Seung Pil Jung (ORCID: https://orcid.org/0000-0003-3967-2974)
- Sangmin Kim (ORCID: https://orcid.org/0000-0003-3466-8634)
- Jeong Eon Lee (ORCID: https://orcid.org/0000-0003-0037-2456)
- Yisun Jeong
- Sun Young Yoon (ORCID: https://orcid.org/0000-0002-4320-2388)
Institutions
- Korea University (KR)
- Samsung Medical Center (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Pharmacology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1159/000545659
- Citations
- 10
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 10.45
Funders
- National Research Foundation
- National Research Foundation of Korea